Downstream Processing Technology
Separation techniques employing filtration and chromatography are an important step towards isolation and purification of products of interest from cellular material. Downstream processing techniques impact the economics of the manufacturing of pharmaceuticals, biopharmaceuticals, vaccines, enzymes, nutraceuticals, etc. Thus, mastering the science of bioseparations is critical to ensuring the commercial success of products. Considering this, our entry-level course is designed to introduce trainees to the principles of bioseparation techniques employed in the industry, their application, and recent technological advances. The course is structured with a strong emphasis on hands-on experience in our Bio-Pilot Lab, where students will be exposed to real-world problems in bioseparation, process analytics, and economics
Basic Program: Duration of one week
Course Code: DSP 01
Key Learning Outcomes:
To be able to…
- Apply Primary and Secondary purification techniques used in the industry
- Perform Tangential Flow Filtration (TFF) to purify biological products
- Troubleshoot and solve problems encountered during protein purification using Microfiltration (MF) and Ultra filtration (UF)
- Apply the principles of TFF design, process development and product economics.
- Employ the different types of chromatography for purifying proteins
Advanced Program: Duration of one month
Course Code: DSP 02
Key Learning Outcomes:
To be able to…
- Apply Primary and Secondary purification techniques used in the industry
- Perform Tangential Flow Filtration (TFF) to purify biological products
- Optimize TFF process parameters using different types of slurry.
- Prepare buffers for the filtration and chromatographic techniques.
- Apply micro-, ultra-, and diafiltration techniques to recover cells, perform buffer exchange, and concentrate the purified product.
- Optimize process parameters for all types of chromatography for purifying proteins
- Optimize and perform bio-analytical assays for quantifying purified proteins
- Validate equipment performance qualification
To obtain more information, you could connect with us at learn@biozeen.com